Head to Head

Updated June 3, 2026 from live stats

Adonai Mitchell vs Brandon AiyukWho should you start in 2026 fantasy football?

Brandon Aiyuk is the better fantasy start for 2026, averaging 11.8 PPG to Adonai Mitchell's 7.8 in 2025. Full head to head breakdown below.

The Bottom Line

Brandon Aiyuk is the better fantasy play this season.

Brandon Aiyuk is the better play on a neutral week. 11.8 PPG with 762 yards gives a reliable baseline. Adonai Mitchell at 7.8 PPG is not far behind and could win specific weeks where matchup and game script align. Draft Brandon Aiyuk higher, but do not fade Adonai Mitchell entirely.

Moderate confidence: stats favor the leader, but matchup variance could flip this weekly.

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WRIndianapolis Colts#99

Adonai Mitchell

PPG

7.8

Games

Rec

Rec Yds

558

Rec TDs

Targets

Bye

Week 14

WRSan Francisco 49ers#99PPG LEADER

Brandon Aiyuk

PPG

11.8

Games

Rec

Rec Yds

762

Rec TDs

Targets

Bye

Week 9

The Edge Chart

Adonai Mitchell

Brandon Aiyuk

Head to Head

7.8 PPG11.8 PPG

16 GP13 GP

Bye: Week 14Bye: Week 9

Fantasy Tiers

Adonai Mitchell: Tier 5 (Deep League) WR (ranked #99 at the position). Brandon Aiyuk: Tier 5 (Deep League) WR (ranked #99 at the position). Among the top 50 wide receivers this season, Adonai Mitchell is producing at 35% of elite pace and Brandon Aiyuk at 54%. These two are close enough in the rankings that weekly matchup should dictate your start.

Adonai Mitchell vs Brandon Aiyuk: The Full Breakdown

If you are choosing between Adonai Mitchell and Brandon Aiyuk for your lineup, you are not alone. Adonai Mitchell finished the 2025 season at 7.8 PPG for the Indianapolis Colts (16 games), and Brandon Aiyuk averaged 11.8 for the San Francisco 49ers (13 games).

That 4.0-point weekly advantage for Brandon Aiyuk is meaningful but not automatic. Fantasy football is a week-to-week sport, and the answer to "who should I start" often changes based on opponent, recent form, and game environment. Season averages set the baseline; weekly context makes the call.

Both are workload receivers with similar target shares. Adonai Mitchell turned 68 targets into 558 yards and 3 touchdowns, while Brandon Aiyuk converted 82 looks into 762 yards and 5 scores. When target volume is this close, game script and defensive matchup typically decide the weekly winner.

One scheduling note: Adonai Mitchell is off Week 14 and Brandon Aiyuk Week 9. If these two are on your roster, you will need a fill-in wide receiver for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.

Trade Value + Dynasty Outlook

Brandon Aiyuk is a buy in trades where the other manager is chasing upside at a different position. Adonai Mitchell is a hold unless you can flip him for a positional upgrade elsewhere on your roster. Dynasty outlook: Adonai Mitchell (age 27) is in the middle of his productive window. Stable dynasty value. Brandon Aiyuk (age 27) is in the middle of his productive window. Stable dynasty value.

Did You Know?

•Brandon Aiyuk outscored Adonai Mitchell by a projected 68 total fantasy points over a full 17-game season.
•Adonai Mitchell played 16 games in 2025 compared to Brandon Aiyuk's 13. That durability gap means Adonai Mitchell contributed more total fantasy points even before you look at per-game averages.
•Brandon Aiyuk scored 5 total touchdowns in 2025 (0.4 per game), making him one of the more reliable scoring options at wide receiver.
•Brandon Aiyuk saw 82 targets in 2025. Target volume is the single strongest predictor of weekly PPR production at the wide receiver position.

Detailed Stat Breakdown

Adonai Mitchell vs Brandon Aiyuk: 2025 fantasy football stat comparison in the half-PPR scoring format.
Stat	Adonai Mitchell	Brandon Aiyuk
PPG (Half-PPR)	7.8	11.8
Games Played	16	13
Total Fantasy Pts (est.)	125	153
Receptions	42	58
Rec/Game	2.6	4.5
Receiving Yards	558	762
Rec Yds/Game	34.9	58.6
Receiving TDs	3	5
Targets	68	82
Target Share/Game	4.3	6.3
Bye Week	Week 14	Week 9

Summary

The 2025 numbers favor Brandon Aiyuk at 11.8 PPG, 4.0 points per game above Adonai Mitchell's 7.8. But season stats only tell part of the story. DraftCall's AI factors in weekly matchup, recent form, and injury status to give you a verdict that updates with the latest data.

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Frequently Asked Questions

Should I start Adonai Mitchell or Brandon Aiyuk in fantasy football?▾

Based on 2025 season averages, Brandon Aiyuk has the edge at 11.8 PPG compared to Adonai Mitchell's 7.8 PPG. However, the best start depends on weekly matchup, recent form, and injury status. DraftCall's app provides real-time AI-powered verdicts that factor in all of these variables.

How many fantasy points did Adonai Mitchell and Brandon Aiyuk average in 2025?▾

Adonai Mitchell averaged 7.8 fantasy points per game (half-PPR) across 16 games in 2025. Brandon Aiyuk averaged 11.8 PPG over 13 games. That is a difference of 4.0 points per game.

When are Adonai Mitchell and Brandon Aiyuk's bye weeks in 2026?▾

Adonai Mitchell (IND) has a bye in Week 14, and Brandon Aiyuk (SF) has a bye in Week 9. Plan your roster accordingly if you are carrying both players.

Is Adonai Mitchell or Brandon Aiyuk a better fantasy wide receiver in 2026?▾

Brandon Aiyuk outscored Adonai Mitchell by 4.0 PPG in 2025, which gives him the edge heading into 2026. For a week-by-week verdict, DraftCall's AI analyzes matchup quality and recent trends in real time.