Alexander Mattison vs James Cook: The Full Breakdown
James Cook and Alexander Mattison are at different tiers heading into 2026. The Buffalo Bills running back averaged 16.8 PPG in 2025, a full 11.5 points per game ahead of Alexander Mattison's 5.3 with the Las Vegas Raiders. That kind of gap doesn't close on matchup alone.
That 11.5-point weekly advantage for James Cook is meaningful but not automatic. Fantasy football is a week-to-week sport, and the answer to "who should I start" often changes based on opponent, recent form, and game environment. Season averages set the baseline; weekly context makes the call.
Both profile as early-down workhorses. Alexander Mattison ran for 255 yards and 2 touchdowns; James Cook posted 1621 and 12. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
Alexander Mattison has his bye in Week 10, and James Cook rests in Week 7. Managers rostering both need waiver wire depth at running back for those two weeks, and that is exactly the kind of planning DraftCall's matchup engine surfaces automatically so you are not scrambling on a Sunday morning.
