Brandon Aiyuk vs Deebo Samuel Sr.: The Full Breakdown
Brandon Aiyuk and Deebo Samuel Sr. are both viable fantasy wide receivers heading into 2026, but their 2025 production tells two different stories. Brandon Aiyuk averaged 11.8 PPG across 13 games with the San Francisco 49ers, while Deebo Samuel Sr. posted 9.5 PPG in 16 appearances for the Washington Commanders.
A 2.3-PPG gap gives Brandon Aiyuk the edge on paper, but paper does not account for Thursday night matchups, weather games, or a star defender returning from injury. The real question is not who was better in 2025, but who is the better start this specific week.
Both are workload receivers with similar target shares. Brandon Aiyuk turned 82 targets into 762 yards and 5 touchdowns, while Deebo Samuel Sr. converted 99 looks into 727 yards and 5 scores. When target volume is this close, game script and defensive matchup typically decide the weekly winner.
One scheduling note: Brandon Aiyuk is off Week 9 and Deebo Samuel Sr. Week 7. If these two are on your roster, you will need a fill-in wide receiver for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
