Brandon Aiyuk vs DeVonta Smith: The Full Breakdown
If you are choosing between Brandon Aiyuk and DeVonta Smith for your lineup, you are not alone. Brandon Aiyuk finished the 2025 season at 11.8 PPG for the San Francisco 49ers (13 games), and DeVonta Smith averaged 9.6 for the Philadelphia Eagles (17 games).
That 2.2-point weekly advantage for Brandon Aiyuk is meaningful but not automatic. Fantasy football is a week-to-week sport, and the answer to "who should I start" often changes based on opponent, recent form, and game environment. Season averages set the baseline; weekly context makes the call.
Target volume is the story here. DeVonta Smith saw 113 targets in 2025, while Brandon Aiyuk drew 82. That workload gap usually translates into a higher weekly floor for DeVonta Smith, even in weeks where Brandon Aiyuk posts the bigger ceiling game. Consistency-minded managers lean toward target share; boom-bust managers chase the upside.
One scheduling note: Brandon Aiyuk is off Week 9 and DeVonta Smith Week 10. If these two are on your roster, you will need a fill-in wide receiver for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
