Brandon Aiyuk vs Keon Coleman: The Full Breakdown
If you are choosing between Brandon Aiyuk and Keon Coleman for your lineup, you are not alone. Brandon Aiyuk finished the 2025 season at 11.8 PPG for the San Francisco 49ers (13 games), and Keon Coleman averaged 7.0 for the Buffalo Bills (12 games).
That 4.8-point weekly advantage for Brandon Aiyuk is meaningful but not automatic. Fantasy football is a week-to-week sport, and the answer to "who should I start" often changes based on opponent, recent form, and game environment. Season averages set the baseline; weekly context makes the call.
Both are workload receivers with similar target shares. Brandon Aiyuk turned 82 targets into 762 yards and 5 touchdowns, while Keon Coleman converted 59 looks into 404 yards and 4 scores. When target volume is this close, game script and defensive matchup typically decide the weekly winner.
Bye weeks matter for roster construction: Brandon Aiyuk sits Week 9 while Keon Coleman is off Week 7. If you are deciding between the two as a season-long roster hold, the staggered byes actually work in your favor.
