Brandon Aiyuk vs Tyler Lockett: The Full Breakdown
If you are choosing between Brandon Aiyuk and Tyler Lockett for your lineup, you are not alone. Brandon Aiyuk finished the 2025 season at 11.8 PPG for the San Francisco 49ers (13 games), and Tyler Lockett averaged 6.9 for the Seattle Seahawks (15 games).
That 4.9-point weekly advantage for Brandon Aiyuk is meaningful but not automatic. Fantasy football is a week-to-week sport, and the answer to "who should I start" often changes based on opponent, recent form, and game environment. Season averages set the baseline; weekly context makes the call.
Both are workload receivers with similar target shares. Brandon Aiyuk turned 82 targets into 762 yards and 5 touchdowns, while Tyler Lockett converted 72 looks into 548 yards and 2 scores. When target volume is this close, game script and defensive matchup typically decide the weekly winner.
One scheduling note: Brandon Aiyuk is off Week 9 and Tyler Lockett Week 10. If these two are on your roster, you will need a fill-in wide receiver for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
