Brock Purdy vs Shedeur Sanders: Who Should You Start?
There is a real production gap between these two quarterbacks. Brock Purdy (San Francisco 49ers) averaged 20.8 PPG over 9 games in 2025, outscoring Shedeur Sanders (Cleveland Browns, 11.9 PPG) by 8.9 points per week. That separation would need a significant matchup swing to overcome.
That 8.9-point weekly advantage for Brock Purdy is meaningful but not automatic. Fantasy football is a week-to-week sport, and the answer to "who should I start" often changes based on opponent, recent form, and game environment. Season averages set the baseline; weekly context makes the call.
Both lean on arm talent and offensive scheme as traditional pocket passers. Brock Purdy threw for 2167 yards and 20 touchdowns, while Shedeur Sanders posted 1400 yards and 7 scores. Volume, red zone efficiency, and game script are the key week-to-week differentiators when neither carries rushing upside.
One scheduling note: Brock Purdy is off Week 9 and Shedeur Sanders Week 10. If these two are on your roster, you will need a fill-in quarterback for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.