Devin Singletary vs James Cook: Who Should You Start?
The numbers tell a clear story here. James Cook put up 16.8 fantasy points per game for the Buffalo Bills in 2025, while Devin Singletary managed 5.9 across 17 games with the New York Giants. A 10.9-point weekly edge is substantial at the running back position.
James Cook carries a 10.9-point PPG advantage from the 2025 season. That baseline matters, but it is one input among several. Matchup difficulty, scoring trends, and injury reports move the needle week to week, which is why the best answer changes depending on when you are asking.
Both profile as early-down workhorses. Devin Singletary ran for 437 yards and 5 touchdowns; James Cook posted 1621 and 12. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
Bye weeks matter for roster construction: Devin Singletary sits Week 11 while James Cook is off Week 12. If you are deciding between the two as a season-long roster hold, the staggered byes actually work in your favor.
