Dylan Sampson vs Kyren Williams: Who Should You Start?
There is a real production gap between these two running backs. Kyren Williams (Los Angeles Rams) averaged 14.4 PPG over 17 games in 2025, outscoring Dylan Sampson (Cleveland Browns, 4.7 PPG) by 9.7 points per week. That separation would need a significant matchup swing to overcome.
A 9.7-PPG gap gives Kyren Williams the edge on paper, but paper does not account for Thursday night matchups, weather games, or a star defender returning from injury. The real question is not who was better in 2025, but who is the better start this specific week.
Both profile as early-down workhorses. Dylan Sampson ran for 175 yards and undefined touchdowns; Kyren Williams posted 1252 and 10. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
One scheduling note: Dylan Sampson is off Week 10 and Kyren Williams Week 6. If these two are on your roster, you will need a fill-in running back for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
