Isiah Pacheco vs TreVeyon Henderson: Who Should You Start?
Deciding between Isiah Pacheco and TreVeyon Henderson is a common lineup dilemma for fantasy managers. The Detroit Lions running back put up 6.0 PPG in 2025 over 13 games; TreVeyon Henderson of the New England Patriots averaged 11.1 in 17. A 5.1-point margin that could shift on any given week.
The per-game difference of 5.1 points favors TreVeyon Henderson, though savvy managers know that gap can shrink or widen depending on the weekly slate. Defensive matchup, recent scoring trends, and health status all shift the calculus from one running back to the other.
Both profile as early-down workhorses. Isiah Pacheco ran for 462 yards and 1 touchdowns; TreVeyon Henderson posted 911 and 9. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
One scheduling note: Isiah Pacheco is off Week 5 and TreVeyon Henderson Week 14. If these two are on your roster, you will need a fill-in running back for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
