James Cook vs Khalil Herbert: The Full Breakdown
The numbers tell a clear story here. James Cook put up 16.8 fantasy points per game for the Buffalo Bills in 2025, while Khalil Herbert managed 5.8 across 12 games with the Cincinnati Bengals. A 11.0-point weekly edge is substantial at the running back position.
That 11.0-point weekly advantage for James Cook is meaningful but not automatic. Fantasy football is a week-to-week sport, and the answer to "who should I start" often changes based on opponent, recent form, and game environment. Season averages set the baseline; weekly context makes the call.
Both profile as early-down workhorses. James Cook ran for 1621 yards and 12 touchdowns; Khalil Herbert posted 248 and 2. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
Bye weeks matter for roster construction: James Cook sits Week 7 while Khalil Herbert is off Week 12. If you are deciding between the two as a season-long roster hold, the staggered byes actually work in your favor.
