Head to Head · Start / Sit

James Cook vs TreVeyon Henderson

Fantasy Football Comparison for the 2026 NFL Season

RBBuffalo BillsPPG LEADER

James Cook

PPG

16.8

Games

Rush Yds

1,621

Rush TDs

Rec

Rec Yds

291

Bye

Week 12

RBNew England Patriots

TreVeyon Henderson

PPG

11.1

Games

Rush Yds

911

Rush TDs

Rec

Rec Yds

221

Bye

Week 14

Head to Head

16.8 PPG11.1 PPG

17 GP17 GP

Bye: Week 12Bye: Week 14

James Cook vs TreVeyon Henderson: Who Should You Start?

James Cook and TreVeyon Henderson are both viable fantasy running backs heading into 2026, but their 2025 production tells two different stories. James Cook averaged 16.8 PPG across 17 games with the Buffalo Bills, while TreVeyon Henderson posted 11.1 PPG in 17 appearances for the New England Patriots.

A 5.7-PPG gap gives James Cook the edge on paper, but paper does not account for Thursday night matchups, weather games, or a star defender returning from injury. The real question is not who was better in 2025, but who is the better start this specific week.

Both profile as early-down workhorses. James Cook ran for 1621 yards and 12 touchdowns; TreVeyon Henderson posted 911 and 9. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.

Bye weeks matter for roster construction: James Cook sits Week 12 while TreVeyon Henderson is off Week 14. If you are deciding between the two as a season-long roster hold, the staggered byes actually work in your favor.

The Bottom Line

James Cook outscored TreVeyon Henderson by 5.7 PPG in 2025 (16.8 to 11.1). That production gap is the baseline, but weekly context shifts the answer. DraftCall analyzes matchup difficulty, scoring trends, and health data to deliver a clear start or sit recommendation backed by real reasoning.

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Frequently Asked Questions

Should I start James Cook or TreVeyon Henderson in fantasy football?▾

Based on 2025 season averages, James Cook has the edge at 16.8 PPG compared to TreVeyon Henderson's 11.1 PPG. However, the best start depends on weekly matchup, recent form, and injury status. DraftCall's app provides real-time AI-powered verdicts that factor in all of these variables.

How many fantasy points did James Cook and TreVeyon Henderson average in 2025?▾

James Cook averaged 16.8 fantasy points per game (half-PPR) across 17 games in 2025. TreVeyon Henderson averaged 11.1 PPG over 17 games. That is a difference of 5.7 points per game.

When are James Cook and TreVeyon Henderson's bye weeks in 2026?▾

James Cook (BUF) has a bye in Week 12, and TreVeyon Henderson (NE) has a bye in Week 14. Plan your roster accordingly if you are carrying both players.

Is James Cook or TreVeyon Henderson a better fantasy running back in 2026?▾

James Cook outscored TreVeyon Henderson by 5.7 PPG in 2025, which gives him the edge heading into 2026. For a week-by-week verdict, DraftCall's AI analyzes matchup quality and recent trends in real time.