Miles Sanders vs Saquon Barkley: The Full Breakdown
There is a real production gap between these two running backs. Saquon Barkley (Philadelphia Eagles) averaged 13.4 PPG over 16 games in 2025, outscoring Miles Sanders (Dallas Cowboys, 5.7 PPG) by 7.7 points per week. That separation would need a significant matchup swing to overcome.
That 7.7-point weekly advantage for Saquon Barkley is meaningful but not automatic. Fantasy football is a week-to-week sport, and the answer to "who should I start" often changes based on opponent, recent form, and game environment. Season averages set the baseline; weekly context makes the call.
Both profile as early-down workhorses. Miles Sanders ran for 117 yards and 1 touchdowns; Saquon Barkley posted 1140 and 7. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
One scheduling note: Miles Sanders is off Week 14 and Saquon Barkley Week 10. If these two are on your roster, you will need a fill-in running back for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
