Christian McCaffrey vs Kyren Williams: Who Should You Start?
There is a real production gap between these two running backs. Christian McCaffrey (San Francisco 49ers) averaged 21.5 PPG over 17 games in 2025, outscoring Kyren Williams (Los Angeles Rams, 14.4 PPG) by 7.1 points per week. That separation would need a significant matchup swing to overcome.
Christian McCaffrey carries a 7.1-point PPG advantage from the 2025 season. That baseline matters, but it is one input among several. Matchup difficulty, scoring trends, and injury reports move the needle week to week, which is why the best answer changes depending on when you are asking.
Christian McCaffrey is the receiving back in this matchup, turning 102 targets into 924 yards, while Kyren Williams profiles as a more traditional rusher with 1252 rushing yards and 10 touchdowns. In PPR and half-PPR formats Christian McCaffrey carries the higher weekly floor. In standard leagues the gap tightens considerably.
One scheduling note: Christian McCaffrey is off Week 9 and Kyren Williams Week 6. If these two are on your roster, you will need a fill-in running back for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
