Kyren Williams vs Zonovan Knight: Who Should You Start?
There is a real production gap between these two running backs. Kyren Williams (Los Angeles Rams) averaged 14.4 PPG over 17 games in 2025, outscoring Zonovan Knight (Arizona Cardinals, 6.8 PPG) by 7.6 points per week. That separation would need a significant matchup swing to overcome.
That 7.6-point weekly advantage for Kyren Williams is meaningful but not automatic. Fantasy football is a week-to-week sport, and the answer to "who should I start" often changes based on opponent, recent form, and game environment. Season averages set the baseline; weekly context makes the call.
Both profile as early-down workhorses. Kyren Williams ran for 1252 yards and 10 touchdowns; Zonovan Knight posted 269 and 4. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
One scheduling note: Kyren Williams is off Week 6 and Zonovan Knight Week 11. If these two are on your roster, you will need a fill-in running back for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
