DraftCall
DraftCallFantasy Football

Head to Head · Start / Sit

Bo Nix vs Patrick Mahomes

Fantasy Football Comparison for the 2026 NFL Season

QBDenver Broncos
Bo Nix
PPG
18.6
Games
17
Pass Yds
3,931
Pass TDs
25
Rush Yds
356
Rush TDs
5
Bye
Week 14
QBKansas City ChiefsPPG LEADER
Patrick Mahomes
PPG
21.2
Games
14
Pass Yds
3,587
Pass TDs
22
Rush Yds
422
Rush TDs
5
Bye
Week 6

Head to Head

18.6 PPG21.2 PPG
17 GP14 GP
Bye: Week 14Bye: Week 6

Bo Nix vs Patrick Mahomes: Who Should You Start?

Bo Nix and Patrick Mahomes are both viable fantasy quarterbacks heading into 2026, but their 2025 production tells two different stories. Bo Nix averaged 18.6 PPG across 17 games with the Denver Broncos, while Patrick Mahomes posted 21.2 PPG in 14 appearances for the Kansas City Chiefs.

A 2.6-PPG gap gives Patrick Mahomes the edge on paper, but paper does not account for Thursday night matchups, weather games, or a star defender returning from injury. The real question is not who was better in 2025, but who is the better start this specific week.

Patrick Mahomes offers meaningful rushing upside with 422 yards on the ground in 2025, which separates his floor from a pocket passer like Bo Nix (3931 passing yards, 25 touchdowns). In games where the passing matchup looks ugly, that rushing production can be the entire difference on a start/sit call.

Bo Nix has his bye in Week 14, and Patrick Mahomes rests in Week 6. Managers rostering both need waiver wire depth at quarterback for those two weeks, and that is exactly the kind of planning DraftCall's matchup engine surfaces automatically so you are not scrambling on a Sunday morning.

The Bottom Line

Patrick Mahomes outscored Bo Nix by 2.6 PPG in 2025 (21.2 to 18.6). That production gap is the baseline, but weekly context shifts the answer. DraftCall analyzes matchup difficulty, scoring trends, and health data to deliver a clear start or sit recommendation backed by real reasoning.

Website vs App

Get the AI verdict on Bo Nix vs Patrick Mahomes

DraftCall's AI analyzes matchup quality, recent trends, injury impact, and game script to give you a clear start/sit recommendation.

See everything in the app →

Frequently Asked Questions

Should I start Bo Nix or Patrick Mahomes in fantasy football?

Based on 2025 season averages, Patrick Mahomes has the edge at 21.2 PPG compared to Bo Nix's 18.6 PPG. However, the best start depends on weekly matchup, recent form, and injury status. DraftCall's app provides real-time AI-powered verdicts that factor in all of these variables.

How many fantasy points did Bo Nix and Patrick Mahomes average in 2025?

Bo Nix averaged 18.6 fantasy points per game (half-PPR) across 17 games in 2025. Patrick Mahomes averaged 21.2 PPG over 14 games. That is a difference of 2.6 points per game.

When are Bo Nix and Patrick Mahomes's bye weeks in 2026?

Bo Nix (DEN) has a bye in Week 14, and Patrick Mahomes (KC) has a bye in Week 6. Plan your roster accordingly if you are carrying both players.

Is Bo Nix or Patrick Mahomes a better fantasy quarterback in 2026?

Patrick Mahomes outscored Bo Nix by 2.6 PPG in 2025, which gives him the edge heading into 2026. For a week-by-week verdict, DraftCall's AI analyzes matchup quality and recent trends in real time.